The Harriet Lane Handbook, published by Elsevier, has been trusted for over 70 years as the #1 source of pediatric point-of-care clinical information. Now, listen to residents and faculty at The Johns Hopkins Hospital discuss case studies and healthcare disparities based on topics from this bestselling book.

Harriet Lane Handbook: Pediatric Insights from The Johns Hopkins Hospital
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The Harriet Lane Handbook, published by Elsevier, has been trusted for over 70 years as the #1 source of pediatric point-of-care clinical information. Now, listen to residents and faculty at The Johns Hopkins Hospital discuss case studies and healthcare disparities based on topics from this bestselling book.
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Publishing Since
8/23/2024
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Recent Episodes

April 22, 2026
Episode 17: Rheumatology: A systematic approach to differentiating the various childhood arthritic conditions
<p><strong>Tolulope Fatola, MD and Julia F. Shalen, MD</strong> from <strong>Johns Hopkins Hospital </strong>discuss <strong>Rheumatology: A systematic approach to differentiating the various childhood arthritic conditions. </strong></p><p><strong>Key takeaways:</strong></p><ul><li>Core diagnostic cues and red flags for common pediatricrheumatic diseases discussed, with quick signs you can check on exam.</li><li>Key physical exam findings and how to differentiateinflammatory vs. noninflammatory presentations in children (joints, skin, mucosal) to guide when to escalate.</li><li>Initial workup steps and criteria for urgent rheumatology referral, including when to order imaging or labs.</li><li>First-line treatment principles in pediatrics: NSAIDs,steroid-sparing approaches, and DMARDs/biologics, with pediatric dosing caveats and vaccine considerations.</li><li>Monitoring and safety considerations for children onimmunomodulatory therapy (growth, infections, lab monitoring, long-term risks).</li><li>Controversies or debated points raised in the episode (e.g., sequencing of DMARDs/biologics, use of steroids, steroid-sparing strategies) with succinct takeaways or guidelines mentioned.</li><li>Practical clinical pearls and common pitfalls for residents(how to simplify complex cases, how to communicate with families, and what to document consistently).</li></ul><p><br></p>

March 16, 2026
Episode 16: End of life decision making in the adolescent palliative care patient
<p><strong>Juliet A. Joseph, MD and Emily Johnson, CRNP</strong> from <strong>Johns Hopkins Hospital </strong>discuss end of life decision makingin the <strong>adolescent palliative care patient</strong>.</p><p>Key takeaways:</p><ul><li>Proactively include PPC in routine care for serious pediatric illnesses.</li><li>Use structured, family-centered conversations to clarify goals, preferences, and trade-offs.</li><li>Leverage a multidisciplinary team to support complex decisions.</li><li>Emphasize clear communication, cultural sensitivity, and ongoing family support.</li><li>Address adolescent autonomy and ethically challenging situations.</li></ul>

February 11, 2026
Episode 15: Initial presentation and workup of acute lymphoblastic leukemia
<p><strong>Katelyn Williams, MD </strong>and<strong> Nathaniel J. Silvestri, MD</strong> from<strong>Johns Hopkins Hospital </strong>discuss the initial presentation and workup of acute lymphoblastic leukemia.</p><p> </p><p>Acute lymphoblastic leukemia (ALL) is the most commonpediatric cancer. Early recognition and prompt workup are critical for improvedoutcomes.</p><p>A case-based conversation featuring a 5-year-old withfatigue, bone pain, pallor, and reduced activity, guided by pediatric hematology/oncology expert input. The discussion outlines red flags, initial laboratory tests, imaging, differential diagnoses, and referral pathways.</p><p> </p><p>Key points:</p><p>Red flags for ALL in children include persistent bone/backpain, refusal to bear weight, unexplained bruising, pallor, and diminishedactivity.</p><p>Comprehensive physical exam should assess forhepatosplenomegaly, lymphadenopathy, and, in boys, testicular involvement.</p><p>Initial laboratory workup (if malignancy is suspected) centers on CBC with differential and reticulocyte count, with attention to red cell indices (MCV, iron studies), hemoglobin, platelets, and neutrophils; LDH and uric acid; CMP and coag studies; and peripheral smear.</p><p>WBC counts can be normal, low, or high at presentation;imaging (e.g., chest X-ray) is considered to evaluate potential mediastinal mass, particularly with risk for T‑cell leukemia.</p><p>Differential includes infectious diseases and rheumatologicconditions; neuroblastoma should be considered in the differential of bone pain.</p><p>Referral to pediatric oncology or the emergency departmentis advised when alarm features or concerning labs are present.</p><p>Management considerations in the ED/outpatient settinginclude non-emergent procedures planning, NPO status when needed, and cautious use of steroids due to risks such as tumor lysis and diagnostic masking.</p><p>Resources and collaboration with oncology, vaccinationconsiderations during therapy, and family education are emphasized.</p><p>Implications: The talk reinforces recognizing early ALLsigns, initiating appropriate labs and imaging, timely referrals, and coordinated care to optimize outcomes.</p><p></p>
17 total episodes available
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Anna Bitners MD
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Courtney Lawrence MD
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