Interviews with top cardiologists and cardiovascular researchers about breakthrough research, clinical trials, and emerging innovations featured in JACC.
How much of the coronary calcium seen on CT is real, and how much is image artifact? In this episode of Behind the Science, Adith Arun sits down with Dr. Doosup Shin to discuss their JACC study, "Photon-Counting Detector CT Reduces Calcium Overestimation Compared with Energy-Integrating Detector CT: Micro-CT Validation in Cadaveric Arteries." Using cadaveric coronary arteries and high-resolution micro-CT as the ground truth, the investigators compared next-generation photon-counting CT (PCCT) with conventional energy-integrating detector CT (EID-CT). Their findings show that PCCT substantially reduces calcium blooming artifact and decreases calcium overestimation, providing a more accurate representation of coronary calcification morphology. This conversation highlights how photon-counting CT may transform the evaluation of coronary artery disease by delivering sharper images, more accurate plaque characterization, and improved clinical decision-making. #PhotonCountingCT #CardiacCT #CoronaryCalciumImaging #CCTA #CoronaryArteryDisease #CalciumScoring #CardiovascularImaging #JACC
11 Aug 2026
Behind the Science: What Muscle Health Reveals About Heart Failure Risk | JACC
How much cardiovascular risk is hidden in the scans we already perform every day? In this episode of Behind the Science, we explore groundbreaking research on imaging-derived sarcopenic obesity and its relationship to heart failure, cardiovascular death, and overall mortality. The discussion highlights how routine cardiac MRI can provide novel insights into muscle health, risk stratification, and the biological pathways linking obesity, aging, and cardiovascular disease. Join us as we examine how imaging, genomics, and transcriptomics come together to identify individuals at higher cardiovascular risk, uncover shared mechanisms between muscle loss and heart failure, and reveal new opportunities for precision cardiology.
28 Jul 2026
Behind the Science: Central, Hematological and Peripheral Effects of Sotatercept | JACC
In this episode of Behind the Science, Dr. Yogesh Reddy joins to explore how sotatercept improves outcomes in pulmonary arterial hypertension (PAH) and why its effects go beyond traditional vasodilation. Using detailed invasive hemodynamic testing, exercise protocols, and skeletal muscle assessment, the study highlights key mechanisms, including reductions in pulmonary vascular resistance, improved right ventricular efficiency, increased hemoglobin, and enhanced oxygen extraction at the muscle level. These findings provide new insight into sotatercept's multi-system effects and help explain the significant improvements in exercise capacity seen in clinical trials—offering important implications for future PAH therapies. #Cardiology #PulmonaryHypertension #PAH #Sotatercept #ACC #JACC #MedicalResearch #HeartHealth
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