Our channel provides longevity, anti-aging and health information. We interview experts in their field to get the latest information in the longevity space. You can also come to our YouTube channel for more information here https://www.youtube.com/channel/UCLFEKx_LchTLy_XwjPToJ3A
Modern Healthspan
Claim This Podcastby Modern Healthspan
4.8(12 reviews)
367 episodes
Updated Daily
Accepts GuestsHas Sponsors
83
Podcast Authority
BetaExcellentBased on show quality, social media presence, reviews, charts, and more
Quality94
Social0
YouTube93
Engagement89
Podcast Overview
Our channel provides longevity, anti-aging and health information. We interview experts in their field to get the latest information in the longevity space. You can also come to our YouTube channel for more information here https://www.youtube.com/channel/UCLFEKx_LchTLy_XwjPToJ3A
Language
🇺🇲
Publishing Since
3/14/2021
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83
Podcast Authority
BetaExcellentBased on show quality, social media presence, reviews, charts, and more
Quality94
Social0
YouTube93
Engagement89
9
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1
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9
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excellent
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Every 5 days
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Recent Episodes
August 10, 2026
How This Peptide Drives Fat Loss & Preserves Muscle | Dr David Lee
<p>USC Gerontology Professor Dr. Changhan David Lee breaks down the discovery of MOTS-c, a novel mitochondrial-derived peptide that functions as an exercise mimetic, cellular stress responder, and immunomodulator.</p><p><br></p><p>Are mitochondria more than just cellular powerhouses? In this episode of Modern Healthspan, Dr David Lee, Associate Professor at the USC Leonard Davis School of Gerontology and co-discoverer of MOTS-c, joins us for a deep dive into the emerging world of mitochondrial-derived peptides (MDPs). Dr. Lee explains how these small microproteins, encoded within the mitochondrial 12S rRNA locus, act as critical retrograde signaling molecules. We explore how MOTS-c translocates to the nucleus during metabolic stress, coordinates with AMPK and hypothalamic POMC neurons, and functions as an interferon-responsive host defense peptide. Additionally, Dr. Lee shares findings from preclinical models examining sarcopenia, muscle homeostasis, and age-related physical capacity, while providing an update on the current regulatory state, WADA anti-doping classification, and human translational pipeline of MDP research.</p><p><br></p><p>🌐Links in this video Dr David Lee's page at USC https://gero.usc.edu/faculty/lee/ </p><p>📚 References & Scientific Papers Mentioned: (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism, 21(3), 443–454. https://pmc.ncbi.nlm.nih.gov/articles/PMC4350682/ (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications, 12(1), 470. https://www.nature.com/articles/s41467-020-20790-0 (2021). Mitohormesis in hypothalamic POMC neurons mediates regular exercise-induced high-turnover metabolism. Cell Metabolism, 33(2), 334–349. https://www.sciencedirect.com/science/article/pii/S1550413121000036 (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism, 28(3), 516–524. (2021). Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes. Cell Reports, 36(4), 109447. MOTS-c Coordinates Inter-Organellar Proteostasis for Adaptation to Chronic Metabolic Stress https://www.biorxiv.org/content/10.64898/2026.06.22.733272v1</p><p><br></p><p>Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder</p><p>Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO</p><p>AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw</p><p>https://www.choosemuse.com</p><p>Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)</p><p>Renue by Science all 10% discount with code MHS https://renuebyscience.com/ </p><p>Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN</p><p>If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan</p><p>You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan</p><p><br></p>
August 3, 2026
LDL Only Matters IF You Have This One Thing | Dr John Osborne
<p>Discover how AI-guided Cardiac CT scanning detects hidden soft plaque and allows preventive cardiology to track and reverse heart disease before symptoms start</p><p><br></p><p>Cardiovascular disease remains the leading cause of mortality worldwide, yet over half of affected individuals experience no warning signs before a major event. In this deep-dive interview, Dr. John Osborne, triple-board-certified preventive cardiologist and Chief Medical Officer at ClearCardio, outlines a paradigm shift from reactive symptom management to proactive disease eradication. Dr. Osborne explains why traditional blood panels and risk calculators often fail at the individual level, how arteries hide soft plaque through outward remodeling, and why standard calcium scores can offer a dangerous false sense of security. Discover how cutting-edge AI-enhanced Coronary CT Angiography (CCTA) allows clinicians to visualize, map, and measure arterial plaque down to $0.1mm. Learn how tailored lifestyle strategies, lipid management, and emerging therapeutics targeting Lp(a) can stabilize and reverse plaque to optimize long-term healthspan.</p><p><br></p><p>🌐Links in this video </p><p>ClearCardio Web Page: https://clearcardio.com/ ClearCardio YouTube Channel : https://www.youtube.com/@ClearCardio PREVENT Online calculator - https://professional.heart.org/en/guidelines-and-statements/prevent-calculator</p><p><br></p><p>Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder</p><p>Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO</p><p>AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw</p><p>https://www.choosemuse.com</p><p>Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)</p><p>Renue by Science all 10% discount with code MHS https://renuebyscience.com/ </p><p>Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN</p><p>If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan</p><p>You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan</p><p><br></p>
July 28, 2026
Age-Reversing Stem Cell Treatment Succeeds in Human Trial | Dr Koji Tanabe
<p>Discover how original Yamanaka co-author Dr. Koji Tanabe uses automated iPSC cassettes and autologous stem cell secretomes to reverse cellular aging and repair damaged joints.</p><p><br></p><p>In this landmark episode of Modern Healthspan, we sit down with Dr. Koji Tanabe, founder and CEO of iPS, Inc. and co-author of the historic 2007 Nobel Prize-winning paper on human-induced pluripotent stem cells (iPSCs). Dr. Tanabe shares how twenty years of technological advancement have raised iPSC reprogramming efficiency from under 1% to over 80%, while cutting manufacturing costs through automated cleanroom cassettes. We discuss practical longevity applications available today, including autologous stem cell banking from a simple blood draw, secretome extract therapies for joint and skin rejuvenation, and Japan's approval of iPSC-derived heart tissue. Finally, Dr. Tanabe offers a critical scientific perspective on in vivo partial reprogramming, detailing the cellular identity loss and tumor risks associated with OSK gene delivery. Watch now to learn where stem cell age reversal truly stands today.</p><p><br></p><p>🌐Links in this video </p><p>I Peace home page https://ipeace.com/en/ For Individuals https://mypeace-personal-ipscbanking.com/en/ Dr Tanabe's YouTube channel: https://www.youtube.com/@UC7Vjvz6sM1Olcw_NOXPIkCw *Scientific Backing & Citations:* 1. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131(5), 861-872. https://doi.org/10.1016/j.cell.2007.11.019 2. Life Biosciences' ER100 In Vivo Partial Reprogramming Phase 1 Clinical Trial (FDA Cleared). 3. Japanese Act on the Safety of Regenerative Medicine (ASRM) (regulatory framework for autologous cellular extract medical services).</p><p><br></p><p>Qitone (10% off: HEALTH10) https://tidd.ly/4jGklry Qitone Esters Powder</p><p>Seeking Health supplements: 10% discount code Richard10 https://crrnt.app/SEEK/-dm0MyrQ, Histamine Nutrients https://crrnt.app/SEEK/EpM7paAO</p><p>AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw</p><p>https://www.choosemuse.com</p><p>Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US)</p><p>Renue by Science all 10% discount with code MHS https://renuebyscience.com/ </p><p>Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN</p><p>If you would like to support our channel please consider signing up on patreon https://patreon.com/ModernHealthspan</p><p>You can also find us on YouTube at https://www.youtube.com/c/modernhealthspan</p><p><br></p>
367 total episodes available with 3 transcripts
Recent guests on Modern Healthspan
Guests from recent episodes — sign up to see every guest that has ever appeared on this show.
Christian Drapeau
Guest
JoAnn Manson
Guest
Dr Stephen Cunnane
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Dr Brad Shoenfeld
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Dr Howard Sesso
Guest
Dr Li Sidong
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Amit Sharma
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Nir Barzilai
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Mikhail Kolonin
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Anurag Singh
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Valter Longo
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Dr Dan Pardi
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Frequently asked questions
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- What is Modern Healthspan?
- How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 9 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
Yes, this podcast regularly features guests.
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