The ImmunoVerse™ is a monthly podcast exploring the past, present and future of immunotherapy and delving into every intricacy of the body's immune system. Hosted by Moffitt Cancer Center President and CEO, Dr. Patrick Hwu, each episode highlights the trailblazing visionaries who are pushing boundaries in this ever-evolving, world-changing field.

The ImmunoVerse™
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Podcast Overview
The ImmunoVerse™ is a monthly podcast exploring the past, present and future of immunotherapy and delving into every intricacy of the body's immune system. Hosted by Moffitt Cancer Center President and CEO, Dr. Patrick Hwu, each episode highlights the trailblazing visionaries who are pushing boundaries in this ever-evolving, world-changing field.
Language
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Publishing Since
4/5/2025
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Recent Episodes

May 21, 2026
Inside the Microbiome: Fiber, Gut Health and Immunotherapy, ft. Dr. Jennifer Wargo
Dr. Patrick Hwu interviews Dr. Jennifer Wargo, a leading researcher, about how the gut microbiome influences cancer development and immunotherapy response, offering insights into future treatment strategies.

April 23, 2026
Reprogramming Metabolism to Power Immunotherapy, ft. Dr. Greg Delgoffe
Dr. Patrick Hwu sits down with Dr. Greg Delgoffe, professor of immunology at the University of Pittsburgh and director of the Tumor Microenvironment Center at UPMC Hillman Cancer Center, to explore how the tumor microenvironment functions as a complex, dynamic ecosystem that shapes the success or failure of cancer immunotherapy. Together, they unpack how tumors are far more than just cancer cells—consisting instead of diverse populations of immune cells, stromal cells, and cancer cells all interacting within a shared and often hostile environment. Dr. Delgoffe explains how cancer cells actively reshape that environment by competing for and consuming key nutrients, effectively starving immune cells and limiting their ability to mount an effective response. The conversation dives into the emerging field of immunometabolism, revealing how metabolic competition within tumors can determine immune cell function and ultimately influence whether immunotherapy works. What You’ll Learn with Dr. Delgoffe What the tumor microenvironment is and why it’s more than just cancer cells. How immune cells and tumor cells compete for space, nutrients and control. How metabolism shapes immune function and cancer’s ability to evade attack. Why understanding these cellular “interactions” is key to improving immunotherapy.

March 26, 2026
Uncovering the Dark Matter of Cancer, ft. Dr. Bernie Fox
Dr. Patrick Hwu sits down with Dr. Bernie Fox, a pioneering immunologist and chief of the Laboratory of Molecular and Tumor Immunology at Providence Cancer Institute. The conversation spans the early days of immunotherapy, including their shared training roots in the NIH Surgery Branch under Dr. Steve Rosenberg, and moves into today’s cutting-edge science. Dr. Fox explains the emerging concept of “dark matter” in cancer biology — the once-dismissed non-coding regions of DNA that may play a pivotal role in tumor progression and immune targeting. He discusses how these regions are now known to produce short-lived proteins that may act as cancer drivers and immunotherapy targets. Importantly, many of these “dark antigens” are shared across tumor types and do not appear in healthy tissue, making them promising targets for vaccines, TCR therapies, and other immune-based treatments. The episode also highlights Fox’s commitment to mentorship, the evolution of the Society for Immunotherapy of Cancer (SITC), and the future potential of dark genome research in cancer and beyond. What You'll Learn • How early immunotherapy research at the NCI helped prove that genetically engineered T cells can fight cancer. • What scientists mean by the “dark genome” and why it matters in cancer. • How hidden regions of DNA can produce proteins that help tumors grow and spread. • Why many tumor antigens may come from non-canonical DNA regions rather than mutations. • How researchers are exploring vaccines and engineered T cells to target these antigens. • Why discoveries in the dark genome could impact many diseases beyond cancer.
16 total episodes available with 1 transcripts
Recent guests on The ImmunoVerse™
Guests from recent episodes — sign up to see every guest that has ever appeared on this show.
Dr Jennifer Wargo
Guest
Dr Drew Pardoll
Guest
Dr Suzanne Topalian
Guest
Dr Robert Vonderheide
Guest
Sandra Demaria
Guest
Dr Mario Sznol
Guest
Dr Fred Locke
Guest
Dr Thomas Gajewski
Guest
Dr Elizabeth Jaffee
Guest
Dr James Mulé
Guest
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Frequently asked questions
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- What is The ImmunoVerse™?
- How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
Yes, this podcast regularly features guests.
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