In each episode, we’ll meet renowned medical experts, specialists and pioneers who’ve influenced the way certain conditions and diseases are understood and treated. We focus on giving you the information you need to understand the root cause, symptoms and treatments available for specific medical conditions.
The Root Cause Medicine Podcast
Claim This Podcastby Rupa Health
4.8(560 reviews)
338 episodes
Updated Daily
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98
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Podcast Overview
In each episode, we’ll meet renowned medical experts, specialists and pioneers who’ve influenced the way certain conditions and diseases are understood and treated. We focus on giving you the information you need to understand the root cause, symptoms and treatments available for specific medical conditions.
Language
🇺🇲
Publishing Since
10/6/2021
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Recent Episodes
May 21, 2026
New GLP1 Risks & Exercise as a Mental Health Prescription
Host Dr. James Maskell and Dr. Sarah Hall discuss emerging GLP-1 risks and exercise as a mental health prescription, offering practical clinical insights for patient care.
May 14, 2026
Inside Mosaic Diagnostics
<h1><strong style="background-color: transparent;">Inside Mosaic Diagnostics: Clinical Applications of Organic Acids, Environmental, and Microbiome Testing</strong></h1><h2><br></h2><h2><strong style="background-color: transparent;">What Is Mosaic Diagnostics and How Are Its Lab Tests Used in Clinical Practice?</strong></h2><p><br></p><p><span style="background-color: transparent;">In this episode, Dr. Kate Kresge speaks with Mosaic Diagnostics CEO Scott Mattivi and Chief Medical Officer Dr. Kurt Woeller to explore how specialty laboratory testing is used in functional and integrative medicine. Mosaic Diagnostics offers tests such as </span><strong style="background-color: transparent;">organic acids, environmental exposure biomarkers, and microbiome assessments</strong><span style="background-color: transparent;">, which may help clinicians evaluate complex, multi-system presentations. These tools are typically used as part of a </span><strong style="background-color: transparent;">systems-based clinical framework</strong><span style="background-color: transparent;">, supporting pattern recognition rather than serving as standalone diagnostic tests. The discussion also explores how clinicians interpret multi-system lab data, the role of practitioner education, and how emerging technologies—such as AI-assisted tools—may support clinical efficiency and decision-making.</span></p><h2><br></h2><h2><strong style="background-color: transparent;">What Does Mosaic Diagnostics Test For?</strong></h2><p><br></p><p><span style="background-color: transparent;">Mosaic Diagnostics provides specialty lab testing commonly used in integrative and functional medicine, including:</span></p><ul><li><strong style="background-color: transparent;">Organic acids testing (OAT)</strong></li><li><strong style="background-color: transparent;">Environmental toxin and mycotoxin testing</strong></li><li><strong style="background-color: transparent;">Microbiome and gastrointestinal assessments</strong></li><li><strong style="background-color: transparent;">Metabolic and immune-related biomarkers</strong></li></ul><p><br></p><p><span style="background-color: transparent;">These tests are designed to provide insight into </span><strong style="background-color: transparent;">biochemical pathways, microbial activity, and environmental exposures</strong><span style="background-color: transparent;">. Results are generally interpreted alongside clinical history, symptoms, and conventional labs to support individualized care.</span></p><h2><br></h2><h2><strong style="background-color: transparent;">Key Clinical Insights</strong></h2><h3><br></h3><h3><strong style="background-color: transparent;">What Is Organic Acids Testing (OAT)?</strong></h3><p><span style="background-color: transparent;">Organic acids testing evaluates urinary metabolites involved in intermediary metabolism. It may provide insight into:</span></p><ul><li><span style="background-color: transparent;">Mitochondrial function</span></li><li><span style="background-color: transparent;">Nutrient metabolism (e.g., B vitamins, amino acids)</span></li><li><span style="background-color: transparent;">Oxidative stress patterns</span></li><li><span style="background-color: transparent;">Microbial activity</span></li></ul><p><span style="background-color: transparent;">When interpreted within clinical context, OAT may support identification of metabolic patterns and inform clinical hypotheses (Gallagher, 2018).</span></p><h3><br></h3><h3><strong style="background-color: transparent;">What Does Environmental Toxin Testing Measure?</strong></h3><p><span style="background-color: transparent;">Environmental exposure testing evaluates biomarkers associated with compounds such as:</span></p><ul><li><span style="background-color: transparent;">Mycotoxins</span></li><li><span style="background-color: transparent;">Heavy metals (in some panels)</span></li><li><span style="background-color: transparent;">Industrial chemicals</span></li></ul><p><span style="background-color: transparent;">These tests may help characterize </span><strong style="background-color: transparent;">exposure patterns</strong><span style="background-color: transparent;">, though interpretation can be complex due to variability in exposure timing, metabolism, and elimination. Clinical relevance should be assessed cautiously and within the broader evidence base (Warth, 2013; Owolabi, 2024).</span></p><h3><br></h3><h3><strong style="background-color: transparent;">How Are Specialty Lab Tests Used in Functional Medicine?</strong></h3><p><span style="background-color: transparent;">Specialty lab testing is often used to support </span><strong style="background-color: transparent;">systems-based clinical reasoning</strong><span style="background-color: transparent;">, including:</span></p><ul><li><span style="background-color: transparent;">Identifying patterns across metabolic, immune, and gastrointestinal systems</span></li><li><span style="background-color: transparent;">Generating clinical hypotheses</span></li><li><span style="background-color: transparent;">Guiding further testing or interventions</span></li></ul><p><span style="background-color: transparent;">Importantly, these tests are </span><strong style="background-color: transparent;">adjunctive tools</strong><span style="background-color: transparent;"> and are most useful when interpreted alongside clinical presentation and other laboratory data (MedlinePlus, 2023).</span></p><h2><br></h2><h2><strong style="background-color: transparent;">Clinical Takeaways</strong></h2><ul><li><span style="background-color: transparent;">Organic acids testing may offer a systems-level view of metabolism and support pattern recognition when interpreted in context (Gallagher, 2018).</span></li><li><span style="background-color: transparent;">Environmental testing may help identify exposure patterns, though clinical actionability varies (Warth, 2013; Owolabi, 2024).</span></li><li><span style="background-color: transparent;">Specialty lab testing is most effective when used to evaluate </span><strong style="background-color: transparent;">patterns across systems</strong><span style="background-color: transparent;">, rather than isolated biomarkers.</span></li><li><span style="background-color: transparent;">Practitioner education plays a key role in appropriate interpretation and application of these tests.</span></li><li><span style="background-color: transparent;">AI tools may enhance data interpretation and workflow efficiency but should be used alongside clinical expertise.</span></li></ul><h2><br></h2><h2><strong style="background-color: transparent;">Who Should Listen to This Episode?</strong></h2><p><span style="background-color: transparent;">This episode is designed for healthcare providers who:</span></p><ul><li><span style="background-color: transparent;">Use or are considering </span><strong style="background-color: transparent;">functional or integrative lab testing</strong></li><li><span style="background-color: transparent;">Work with </span><strong style="background-color: transparent;">complex, chronic, or multi-system conditions</strong></li><li><span style="background-color: transparent;">Want to better understand </span><strong style="background-color: transparent;">organic acids testing or mycotoxin testing</strong></li><li><span style="background-color: transparent;">Are interested in </span><strong style="background-color: transparent;">clinical data interpretation strategies</strong></li><li><span style="background-color: transparent;">Are exploring </span><strong style="background-color: transparent;">AI tools in clinical practice</strong></li></ul><h2><br></h2><h2><strong style="background-color: transparent;">FAQ: Mosaic Diagnostics and Specialty Lab Testing</strong></h2><h3><br></h3><h3><strong style="background-color: transparent;">What Is Mosaic Diagnostics Known For?</strong></h3><p><span style="background-color: transparent;">Mosaic Diagnostics is known for specialty laboratory testing used in functional and integrative medicine, including organic acids testing, environmental exposure assessments, and microbiome analysis.</span></p><h3><br></h3><h3><strong style="background-color: transparent;">Are Functional Lab Tests Diagnostic?</strong></h3><p><span style="background-color: transparent;">Most functional lab tests are </span><strong style="background-color: transparent;">not diagnostic on their own</strong><span style="background-color: transparent;">. They are typically used as adjunctive tools to support clinical evaluation and guide further investigation.</span></p><h2><br></h2><h2><strong style="background-color: transparent;">Timestamps</strong></h2><p><span style="background-color: transparent;">00:00 – Introduction to Mosaic Diagnostics</span></p><p><span style="background-color: transparent;">03:22 – Origins of organic acids testing</span></p><p><span style="background-color: transparent;">08:26 – Expansion into environmental and microbiome testing</span></p><p><span style="background-color: transparent;">23:41 – Environmental exposures and clinical applications</span></p><p><span style="background-color: transparent;">31:57 – Overview of testing portfolio</span></p><p><span style="background-color: transparent;">42:09 – Organic acids testing in practice</span></p><p><span style="background-color: transparent;">47:41 – Innovation and AI in clinical workflows</span></p><h2><br></h2><h2><strong style="background-color: transparent;">Sponsor Section</strong></h2><p><span style="background-color: transparent; color: rgb(34, 34, 96);">This episode is sponsored by </span><a href="https://fullscript.com/?utm_source=fame&utm_medium=podcast&utm_campaign=fs_provider_2026-01_fame_2026-sibo-updates" target="_blank" style="background-color: transparent; color: rgb(255, 70, 124);">Fullscript</a><span style="background-color: transparent; color: rgb(34, 34, 96);">, a comprehensive care delivery platform designed to support whole-person, integrative healthcare. </span><a href="https://fullscript.com/?utm_source=fame&utm_medium=podcast&utm_campaign=fs_provider_2026-01_fame_2026-sibo-updates" target="_blank" style="background-color: transparent; color: rgb(255, 70, 124);">Fullscript </a><span style="background-color: transparent; color: rgb(34, 34, 96);">allows clinicians to streamline supplement dispensing, lab ordering, and patient education in one free, centralized system—helping reduce administrative burden while supporting clinical decision-making. For practitioners, </span><a href="https://fullscript.com/?utm_source=fame&utm_medium=podcast&utm_campaign=fs_provider_2026-01_fame_2026-sibo-updates" target="_blank" style="background-color: transparent; color: rgb(255, 70, 124);">Fullscript</a><span style="background-color: transparent; color: rgb(34, 34, 96);"> offers access to professional-grade supplements, evidence-informed protocols, and lab integrations that can support more efficient planning and follow-up. For patients, it provides a clear, organized way to receive recommendations, manage refills, and stay engaged in their care. The goal is not to replace clinical judgment, but to make it easier for clinicians to focus on what matters most: thoughtful, individualized patient care.</span></p><p><br></p><h2><strong style="background-color: transparent;">Disclaimer</strong></h2><p><span style="background-color: transparent;">The views expressed on this podcast are those of the hosts and the guests, and they don't necessarily reflect the views of Fullscript or any affiliated organizations. This podcast is for informational and educational purposes only, and it's not intended to be medical advice. For your safety, always check with your health care provider before making any changes to your health care routine.</span></p><h2><br></h2><h2><strong style="background-color: transparent;">Citations</strong></h2><ol><li><span style="color: rgb(33, 33, 33);">Gallagher RC, Pollard L, Scott AI, Huguenin S, Goodman S, Sun Q; ACMG Biochemical Genetics Subcommittee of the Laboratory Quality Assurance Committee. Laboratory analysis of organic acids, 2018 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2018 Jul;20(7):683-691. doi: 10.1038/gim.2018.45. Epub 2018 Mar 15. PMID: 29543224.</span></li><li><span style="color: rgb(33, 33, 33);">Warth B, Sulyok M, Krska R. LC-MS/MS-based multibiomarker approaches for the assessment of human exposure to mycotoxins. Anal Bioanal Chem. 2013 Jul;405(17):5687-95. doi: 10.1007/s00216-013-7011-1. Epub 2013 Jun 18. PMID: 23774829; PMCID: PMC3695324.</span></li><li>Owolabi, Iyiola & Siwarak, Kawisara & Greer, Brett & Rajkovic, Andreja & Dall’asta, Chiara & Karoonuthaisiri, Nitsara & Uawisetwathana, Umaporn & Elliott, Christopher & Petchkongkaew, Awanwee. (2023). Applications of Mycotoxin Biomarkers in Human Biomonitoring for Exposome-Health Studies: Past, Present, and Future. Exposure and Health. 16. 1-23. 10.1007/s12403-023-00595-4. </li><li><span style="color: rgb(33, 33, 33);">Muñoz JP, Bleak TC, Calaf GM. Glyphosate and the key characteristics of an endocrine disruptor: A review. Chemosphere. 2021 May;270:128619. doi: 10.1016/j.chemosphere.2020.128619. Epub 2020 Oct 19. PMID: 33131751.</span></li></ol>
May 7, 2026
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338 total episodes available with 179 transcripts
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