Your Wellness Besties
Lisette Lopez & Nicole Guzzardi
5.0from 12 ratings
- 13
- Episodes
- 12
- Ratings
- Weekly
- Cadence
- 2026
- First episode
About Your Wellness Besties
Welcome to The Wellness Besties, the podcast for women over 40 who are done being dismissed and ready to take their health seriously. Join besties Lisette and Nicole as they try the treatments, have the real conversations, and figure out midlife health and wellness together. From BHRT to biohacking, morning routines to menopause — nothing is off limits. New episodes every week. Find us on Instagram @yourwellnessbesties_
- Publisher
- Lisette Lopez & Nicole Guzzardi
- Category
- health & fitness
- Language
- en
- Explicit
- No
- First episode
- 28 Jul 2026
- Latest episode
- 20 Oct 2026
Latest episodes
13 episodes in the feed.
20 Oct 2026
High Standards or Just Difficult? What Changed in Our 50s
Are your standards too high, or have you spent years making yourself easier for everyone else? In this episode of Your Wellness Besties, Lisette and Nicole get honest about raising your standards in midlife, asking for what you want, and getting comfortable with people having an opinion about it. Lisette reflects on spending her 30s in survival mode with three kids, saying yes to everything and staying quiet to keep the peace. Nicole shares how accepting unhealthy relationships in her 20s eventually taught her to set boundaries that protect her time and energy. From friendships and relationships to business, fitness, and how you show up for yourself, this conversation explores what happens when your choices finally reflect your worth. We get into: • The difference between high standards and perfectionism • Asking for what you want without apologizing • Charging what you're worth and delegating to reclaim your time • Why some friendships shift when your lifestyle changes • How sobriety helped Lisette gain clarity and bet on herself • Building confidence through action and following through on your commitments If you've been lowering your standards to avoid judgment or keep everyone comfortable, ask yourself: What is keeping the peace costing you? This week's challenge: Write down one standard you've been quietly lowering. What would it take to raise it back up? DM us at @yourwellnessbesties on Instagram. We want to hear your answer. Share this episode with a woman who's ready to raise the bar, and subscribe for new episodes every week. #YourWellnessBesties #HighStandards #MidlifeWellness #KnowYourWorth #SettingBoundaries
13 Oct 2026
Why We Stopped Drinking in Our 50s: Sobriety, Anxiety & What Changed
You don’t have to have a drinking problem to realize drinking is a problem for the life you want. In this episode of Your Wellness Besties, Lisette and Nicole get honest about why they stopped drinking in their 50s, what they miss, and what made them decide they didn’t want to go back. For Lisette, it started with a moment at the shore: drinking at 2 p.m. instead of enjoying the beach with her kids. What began as a 30-day break became a lasting decision. She shares her experience with gray area drinking, the awkwardness of going out sober, and how completing 75 Hard strengthened her commitment. Nicole opens up about how having a sober fiancé supported her decision and why alcohol no longer fit her training, nutrition, and health goals. She shares the changes she noticed in her anxiety, mood, and mental clarity, and why keeping that promise to herself matters. Together, they talk about missing the relaxed feeling of a drink, navigating friendships that changed, and why moderation doesn’t work for everyone. They also share what they gained: mornings without hangovers, more energy for workouts, and greater confidence in their choices. If you’ve been thinking about taking a break or questioning whether alcohol still fits your life, this is an honest conversation about what that change can look like. No judgment. Just two women sharing their experiences. This week’s challenge: Start by paying attention. Notice when you want a drink, how much you’re drinking, and how you feel the next day. Track it and see what you learn. We’re not medical professionals. This episode reflects our personal experiences. If you drink heavily or may be dependent on alcohol, talk to a doctor before stopping. Find us on Instagram @yourwellnessbesties and DM us your questions. Subscribe for new episodes every week. #Sobriety #SoberCurious #MidlifeWellness #YourWellnessBesties #WomenOver50 #AlcoholFree
6 Oct 2026
Our Current Obsessions: Wellness, Beauty & Fitness in Our 50s
What are we actually loving and using, in our 50s? This week, we’re swapping our current obsessions, from strength training and protein staples to skincare, sleep tools, and fall fashion. We’re sharing the routines that keep us consistent, the beauty products we keep reaching for, and our honest thoughts on wellness gadgets, including the Oura Ring, red light masks, and Eight Sleep. Plus, journaling, our favorite sweet treats, and finding your style when the clothes you used to love don’t feel like you anymore. It’s a bestie catch-up full of personal favorites, affordable finds, a few splurges, and the reality of fitting it all into a busy life. What’s your current obsession? Tell us on Instagram @yourwellnessbesties, and share this episode with your bestie! Subscribe so you never miss an episode and share this with a woman in your life who needs this conversation. #YourWellnessBesties #WellnessPodcast #MidlifeWellness #WomenOver40 #WomenOver50 #HealthAfter40 #FitnessOver40 #MidlifeHealth #WellnessJourney #BeautyOver50 #SkincareOver40 #MidlifeTransformation #HealthyLiving
29 Sept 2026
It's Not Too Late: The Lies About Aging We're Done Believing
Your 20s told you who to be. Your 30s told you who to take care of. Your 40s and 50s? They're telling you to cut your hair, cover your arms, and quietly fade out. We're not doing that. In this episode, Lisette and Nicole take apart the outdated rules women in midlife are handed about what to wear, how to act, and what's "too late" to start. Lisette almost talked herself out of a brand event in NYC, intimidated by fashion creators she'd followed for years, until her 23-year-old daughter told her she belonged in that room. She also shares how, after 15 years at home, she wrote "you're not too old and it's not too late" in her journal again and again until she finally believed it and did something about it. Nicole opens up about holding back from showing up online for years out of fear of judgment, even after more than a decade of inspiring women through fitness and wellness. They also cover imposter syndrome, the fear of what people will say when you reinvent yourself, why our mothers seemed so much older at this age (the Golden Girls were our age!), ageism at work, and why starting over now can actually be easier than it was at 25. If you've been told you're too old, too late, or too much, this is your sign. Unshrink. Take up space. The only permission you need is your own. Follow us on Instagram @yourwellnessbesties. New episodes every week. Share this with a woman who needs to hear it. #YourWellnessBesties #WomenOver50 #WomenOver40 #MidlifeWomen #MidlifeTransformation #Reinvention #AgeIsJustANumber #PodcastForWomen #MidlifeWellness #WellnessPodcast
22 Sept 2026
The Mental Health Crisis in Midlife Nobody's Talking About
Ready for an honest conversation about burnout, loneliness, and finding yourself again in midlife? Pull up a chair, because we’re getting real. In this episode of Your Wellness Besties, Lisette and Nicole unpack why so many women feel overwhelmed, invisible, and disconnected from themselves during their 40s and 50s. Between raising children, caring for aging parents, navigating changing relationships, managing careers, and coping with hormonal shifts, women are expected to keep showing up for everyone, even when they’re struggling themselves. Lisette opens up about putting herself last while raising three children and entering perimenopause without realizing what was happening to her body. Nicole shares her experience rebuilding her life after divorce, navigating single motherhood, and discovering strength through bodybuilding. They also discuss the loneliness of midlife, brain fog, depression, burnout, ageism in the workplace, setting boundaries, and their personal experiences with bioidentical hormone replacement therapy. They also share how fitness and community helped them reconnect with themselves. If you’ve been questioning who you are beyond being a mother, wife, caregiver, or professional, this conversation will remind you that you’re not alone and that finding yourself again is possible. Because you deserve to feel like yourself again. And it’s never too late to find her. CHAPTERS: 00:00 Why Midlife Feels So Lonely 01:15 Finding Community and Showing Up 03:25 The Mental Health Reality of Midlife 03:55 Caregiving, Burnout, and Hormonal Changes 09:33 When Did You Stop Being the Main Character? 13:13 Finding Yourself After 40 14:05 Why Fitness Is the Ultimate Life Hack 16:21 Hormones, Burnout, and Getting Help 17:28 Ageism and Starting Over in Midlife 19:42 Learning New Skills at Any Age 24:21 Is Social Media Helping or Hurting Us? 28:46 Our Experiences With BHRT 30:18 Saying No and Setting Boundaries 31:35 You’re Not Alone Follow us on Instagram: @yourwellnessbesties New episodes every week. DM us your questions, we read every one. Subscribe so you never miss an episode, and share this conversation with a woman who needs to hear it. #YourWellnessBesties #MidlifeMentalHealth #WomenOver40 #WomenOver50 #MidlifeWellness #MentalHealthMatters #Burnout #FindingYourself #BHRT #WomensHealth
15 Sept 2026
Marriage, Divorce & Finding Love Again in Midlife
Ready for an honest conversation about love, marriage, divorce, and starting over in midlife? Pull up a chair, because we’re getting REAL about relationships. In this episode of Your Wellness Besties, Lisette and Nicole open up about their completely different relationship journeys. Nicole shares what she learned through two divorces and finding love again later in life, while Lisette talks about what it has taken to build a marriage that has lasted nearly 25 years. Nothing is off limits: knowing when it’s time to stay or walk away, rebuilding after divorce, blended families, resentment during the hard seasons of marriage, dating in midlife, and what happens when two people either evolve together or start growing apart. Nicole gets candid about leaving a toxic relationship with two young children, navigating a second marriage, and eventually meeting Billy and finding love again. She also shares what she’s learned about starting over and why no woman should ever believe she’s stuck simply because of her age or circumstances. Lisette shares the other side of the conversation: the seasons when marriage was HARD. She opens up about raising three babies back-to-back, feeling resentful while her husband worked long hours, and why they continued prioritizing their relationship even when life, work, and kids could easily have pulled them apart. They also get into blended families, friendships and relationship boundaries, keeping your marital problems out of the group chat, dating in your 40s and 50s, and whether you can actually rekindle the spark after decades together. Whether you’re happily married, questioning your relationship, divorced, dating again, or simply wondering what love looks like in this chapter of life, this conversation is for you. Because starting over doesn’t mean you failed—and staying together doesn’t mean you got lucky. Both take courage, self-awareness, and knowing what you’re willing to fight for. Find us on Instagram @yourwellnessbesties. New episodes every week. DM us your questions, we read every single one. Subscribe so you never miss an episode, and send this one to a woman who needs this conversation. #YourWellnessBesties #MidlifeRelationships #WomenOver40 #WomenOver50 #MarriageAfter40 #DatingAfterDivorce #DatingOver50 #MidlifeWomen #StartingOver #Marriage #Divorce #Relationships #MidlifeTransformation
8 Sept 2026
How to Find Your People in Midlife: Why Friendship Matters More Than Ever
Ready to find your wellness tribe? Pull up a chair because we're getting real about friendships after 40. In this episode of Your Wellness Besties, Lisette and Nicole dive deep into the reality of midlife friendships, why we all need a wellness bestie, and the exciting announcement of their upcoming Wellness Besties Retreats. They share their vision for creating a community of like minded women who can come together for a few days of wellness, connection, and real conversations about the things that matter most in midlife. This conversation gets honest about how friendships change as you get older. Lisette opens up about moving to New Jersey nine months pregnant, knowing no one, and having to start over. Nicole shares how she still has lifelong friends from nursery school but also experienced friendships fading after divorce and major life changes. They both talk about the loneliness epidemic for women in midlife and how lifestyle changes, sobriety, kids leaving the house, career shifts, and personal growth can all lead to friendships naturally fading without any big blowout. You'll hear about the red flags they look for now when making new friends. They discuss why surrounding yourself with people who match your energy is non negotiable and how friendships based around drinking often fade when one person decides to get sober. They also talk about the importance of being a girl's girl, showing up for your friends during hard times. They break down the difference between quality and quantity friendships and why having a handful of real friends who support you, inspire you, and hold you accountable is worth more than a room full of fake ones. If you're looking for like minded women, feeling isolated in your wellness journey, or wondering where to find your wellness bestie, this episode gives you practical advice on where to start. From the gym and book clubs to networking events, masterminds, and volunteering, they share actionable ways to put yourself out there and find your tribe. Plus, they reveal details about their upcoming Wellness Besties Retreats starting locally in New Jersey this fall and expanding to destination retreats in 2027. If you've been craving connection, community, and a space where you can show up as your authentic self, this is the episode you need to hear. Find us on Instagram @yourwellnessbesties. New episodes every week. DM us your questions, we read every single one. Subscribe so you never miss an episode and share this with a woman in your life who needs this conversation. #YourWellnessBesties #WellnessPodcast #MidlifeWellness #WomenOver40 #HealthAfter40 #PodcastForWomen #MidlifeHealth #WomenOver50 #WellnessAfter40 #MidlifeTransformation #NoFilter #RealTalk #WomensHealth #HealthyLiving #WellnessJourney
1 Sept 2026
Different Rock Bottoms, Same Glow Up (And You Can Too)
Nicole hit rock bottom in her 20s. Loss, divorce, depression, partying to escape her reality. Lisette never hit rock bottom. She just disappeared, 15 years as a stay-at-home mom, until the day her daughter left for college and she realized she'd never done a single thing just for herself. Two different paths. Same glow up. In this episode of Your Wellness Besties, Lisette and Nicole open up about what it really takes to reinvent yourself in your 40s and 50s. Lisette shares a difficult weekend helping a family member through a mental health crisis, which leads into a powerful conversation about how our choices affect us long term and the importance of making changes before it's too late. She reflects on the moment at 49 when she looked in the mirror, 20 pounds overweight, realizing she'd spent 15 years putting everyone else first, all while unknowingly going through perimenopause. Nicole gets real about her messy 20s, marked by loss, divorce, and depression, and how she started her physical transformation at 30 through bodybuilding. But she reveals that looking good on the outside didn't mean she was mentally healthy. It wasn't until she met her fiancé Billy at 40 that she started doing the real work on her mindset. You'll hear about the fear of failure and the public embarrassment both hosts faced when things didn't work out. Lisette talks about starting an online fashion boutique at 48, running it for two years, then having to shut it down and pivot. Nicole discusses the criticism she faced when she started showing up online, competing, and building her brand, including people unfollowing her the moment she started becoming successful and happy. They dig into imposter syndrome, building confidence through action, and why surrounding yourself with the right people is non-negotiable. Nicole explains how confidence comes from doing the reps and showing up scared. Lisette shares why the way you present yourself is a form of self-respect. They talk about why you're never too old to start over, how to make a list and prioritize what actually matters, and why starting small with one habit at a time is the key to not getting overwhelmed. If you're ready to start over, reinvent yourself, or finally prioritize your own happiness and health in midlife, this episode will give you the encouragement and roadmap you need. Zero filter. Find us on Instagram @yourwellnessbesties. New episodes every week. DM us your questions, we read every single one. Subscribe so you never miss an episode and share this with a woman in your life who needs this conversation. #YourWellnessBesties #WellnessPodcast #MidlifeWellness #WomenOver40 #HealthAfter40 #PodcastForWomen #MidlifeHealth #WomenOver50 #WellnessAfter40 #MidlifeTransformation #NoFilter #RealTalk #WomensHealth #HealthyLiving #WellnessJourney
25 Aug 2026
The Truth About Plastic Surgery, Botox & Treatments in Our 50s
Ready for the most honest conversation about Botox, filler, lasers, and plastic surgery? Pull up a chair because we're spilling everything. In this episode of Your Wellness Besties, Lisette and Nicole get completely transparent about every aesthetic treatment they've ever had done. No gatekeeping, no secrets, just two women in their 50s sharing exactly what they've tried, what worked, what didn't, and what they'd do differently. Nicole shares the details from her 50th birthday party celebration and the surprise performance by freestyle legend Judy Torres, then both hosts dive deep into their personal experiences with Botox, filler, laser treatments, and plastic surgery. This conversation covers it all. Lisette opens up about getting breast implants at 40 and why she's now considering removing her implants after years of rippling. Nicole shares her journey with Botox starting at 35, her experience with Sculptra that went wrong due to her Hashimoto's, and the surgical removal of granulomas that cost her thousands to repair. They break down the difference between various laser treatments like Secret Pro, BBL Halo, and Moxie, why skin tightening treatments didn't work for either of them, and the importance of monthly facials with derma planing and hydra facials. Then they get real about plastic surgery. You'll also hear their thoughts on the stigma around plastic surgery and why so many women lie about what they've had done. They talk about the importance of doing your research before any procedure, not being an impulsive buyer when it comes to your face and body, and why you should never cheap out on treatments. Plus, their honest take on aging gracefully versus getting work done and why women need to stop judging each other's choices. If you've been curious about Botox, confused about which laser treatments actually work, or wondering if plastic surgery is worth it, this episode gives you the full breakdown with zero filter. Find us on Instagram @yourwellnessbesties. New episodes every week. DM us your questions, we read every single one. Subscribe so you never miss an episode and share this with a woman in your life who needs this conversation. #YourWellnessBesties #WellnessPodcast #MidlifeWellness #WomenOver40 #HealthAfter40 #PodcastForWomen #MidlifeHealth #WomenOver50 #WellnessAfter40 #MidlifeTransformation #NoFilter #RealTalk #WomensHealth #HealthyLiving #WellnessJourney
18 Aug 2026
What We're Really Taking: Hormones, Peptides & Supplements in Our 50s
Ready for the most honest conversation about what we're actually putting in our bodies in our 50s? Pull up a chair because we're spilling everything. In this episode of Your Wellness Besties, Lisette and Nicole get completely transparent about their hormone replacement therapy, peptides, and supplements. No gatekeeping, no secrets, just two women in their 50s sharing exactly what they take, why they take it, and what's actually working. Lisette shares her recent trip to Madrid and how she maintained her health routine while traveling, and both hosts dive into their personal experiences with bioidentical hormone replacement therapy after years of struggling with brain fog, depression, anxiety, and feeling completely off. This conversation covers the real story behind BHRT. Nicole opens up about her hysterectomy at 40 and how hormone pellets changed her life within two weeks, lifting the overwhelming depression and anxiety she didn't even realize was hormonal. Lisette shares why she waited 10 years to start BHRT because her doctor scared her with warnings about cancer and blood clots, and how finally getting on testosterone, progesterone, and estradiol brought back her energy, sex drive, and mental clarity. They break down the difference between pellets, creams, and pills, how to adjust your dosage, and why working with a specialist who understands hormones is absolutely critical. Then they get into peptides. From GHK-CU copper peptide for glowing skin and strong nails to BPC157 and TB500 for recovery and inflammation, they share their favorite stacks and individual peptides. Nicole explains why she loves The Glow stack and how everyone keeps complimenting her skin and hair. Lisette reveals why GHK-CU copper peptide is her number one and how cycling on and off has transformed her appearance. They also discuss NAD, why it might not be giving them the energy boost they expected, and which peptides are next on their list to try, including the highly talked about MOTS-c. You'll also hear their thoughts on supplements like creatine, collagen, magnesium, probiotics, and why getting your labs done first is non negotiable before you start taking anything. They talk about the importance of not buying peptides online, working with professionals who can monitor your progress, and why you need to have your lifestyle dialed in with exercise, sleep, and nutrition before adding anything extra. Plus, their honest take on GLP1 weight loss peptides and who they think should or shouldn't consider them. If you've been curious about BHRT, confused about peptides, or wondering what supplements are actually worth your money, this episode gives you the full breakdown with zero filter. Find us on Instagram @yourwellnessbesties. New episodes every week. DM us your questions, we read every single one. Subscribe so you never miss an episode and share this with a woman in your life who needs this conversation. #YourWellnessBesties #WellnessPodcast #MidlifeWellness #WomenOver40 #HealthAfter40 #PodcastForWomen #MidlifeHealth #WomenOver50 #WellnessAfter40 #MidlifeTransformation #NoFilter #RealTalk #WomensHealth #HealthyLiving #WellnessJourney
11 Aug 2026
How We Changed Our Training and Eating After 40
Ready to transform how you think about fitness and food in midlife? Join Lisette and Nicole as they get real about what actually works after 40. In this episode of Your Wellness Besties, the hosts dive deep into their personal journeys with training and nutrition, sharing the mistakes they made in their 20s and 30s and the game changing habits they adopted after 40. Nicole opens up about prepping for her 50th birthday photoshoot and how she maintains her physique with just three days of weight training per week. Lisette shares her transformation from cardio obsessed to strength training convert and how learning to lift weights at 42 completely changed her body composition. This conversation gets honest about the diet culture traps so many women fall into. From the heroin chic era of the 90s to every trendy diet imaginable, both hosts reveal their struggles with restrictive eating, overtraining on cardio, and the fear of getting bulky from weights. They break down exactly how they eat now, why tracking macros was a revelation, and how meal prepping makes consistency possible even with busy schedules. You'll learn why lifting weights is non negotiable for bone density and metabolism in midlife, how to start if you've never touched a weight before, and why eating more food can actually help you lose weight when you're making the right choices. They also discuss giving up gluten, managing autoimmune conditions like Hashimoto's, and finding the balance between discipline and enjoying life with the 80/20 rule. If you're tired of restrictive diets that don't work and cardio that leaves you exhausted with no results, this episode will give you a clear roadmap for building sustainable habits that actually transform your body and health after 40. Find us on Instagram @yourwellnessbesties. New episodes every week. DM us your questions, we read every single one. Subscribe so you never miss an episode and share this with a woman in your life who needs this conversation. #YourWellnessBesties #WellnessPodcast #MidlifeWellness #WomenOver40 #HealthAfter40 #PodcastForWomen #MidlifeHealth #WomenOver50 #WellnessAfter40 #MidlifeTransformation #NoFilter #RealTalk #WomensHealth #HealthyLiving #WellnessJourney
4 Aug 2026
The Habits That Changed Our Lives in Midlife
In this episode of Wellness Besties, Lisette and Nicole talk about the habits that genuinely changed their lives, not surface-level wellness trends. From 5 a.m. wake-ups, sobriety, and more than a decade of journaling to lifting weights instead of only doing cardio and letting go of relationships that no longer feel good, they share the changes that made the biggest difference in midlife. They also discuss how to begin when you do not know where to start: choose one small habit, make it sustainable, and build from there. Plus, they get real about navigating healthier habits when your partner, friends, or routine are not fully on the same page. If you are ready to feel stronger, clearer, and more like yourself in this next chapter, this conversation is for you.
28 Jul 2026
The Midlife Wellness Conversation Nobody Was Having. Until Now.
Hey besties, welcome to our very first episode of The Wellness Besties podcast. I'm Lisette and I'm Nicole and we are two women in our 50s who got tired of not having the real conversation about health and wellness after 40. So we decided to have it ourselves. Out loud. With zero filter. In this episode we're introducing ourselves, the real versions, not the curated ones. We're talking about who we are, how we met, why we started this, and what we actually believe about health and wellness at this stage of life. We get into: Our personal wellness journeys and what woke us both up The habits and mindset shifts that actually changed our lives How to build routines that stick without the overwhelm Why doing this together in community makes all the difference What we've unlearned about wellness and what we swear by now This episode is for the woman who is done with generic advice and ready for something real. Whether you're just starting your wellness journey or you've been at it for years there is something in this conversation for you. We're so glad you're here. Hit play and let's get into it. Find us on Instagram @yourwellnessbesties. New episodes every week. DM us your questions, we read every single one.
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Public platform figures. Ratings count people who left a rating, not total listeners.
- Apple Podcasts (US)
- 5.0 / 5
- 10 ratings
- Spotify
- 5.0 / 5
- 2 ratings
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