Tune into our bi-monthly podcast where we interview experts in the field to broaden the awareness of new HCM studies & advancements!
In the Thick of It
Claim This Podcastby Hypertrophic Cardiomyopathy Medical Society
4.2(5 reviews)
36 episodes
Updated Weekly
Accepts GuestsHas Sponsors
34
Podcast Authority
BetaPoorBased on show quality, social media presence, reviews, charts, and more
Quality22
Social0
YouTube68
Engagement51
Podcast Overview
Tune into our bi-monthly podcast where we interview experts in the field to broaden the awareness of new HCM studies & advancements!
Language
🇺🇲
Publishing Since
6/28/2023
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34
Podcast Authority
BetaPoorBased on show quality, social media presence, reviews, charts, and more
Quality22
Social0
YouTube68
Engagement51
6
Excellent Areas
2
Good Performance
11
Growth Opportunities
excellent
Episode Length
28 minutes
Performing excellently!
good
Show Experience
24 episodes over 1.7 years
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needs improvement
Publishing Consistency
Every 25 days
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Recent Episodes
June 2, 2026
Long-Term Realities: Managing Disease Progression and ICD Selection in Young HCM Patients
<p>Patient advocates Hannah and Bethany Keime from HeartCharged sit down with Dr. John Fritzlen to discuss the long-term journey of living with hypertrophic cardiomyopathy (HCM). The conversation covers the progressive nature of the condition, including the onset of heart failure symptoms, atrial fibrillation, and myocardial remodeling over decades, as well as how advanced diagnostics like cardiopulmonary exercise testing (CPET) help clinicians track subtle declines. Dr. Fritzlen shares tailored approaches for counseling young or newly diagnosed patients, emphasizing the importance of active lifestyle management and proactive treatment strategies like cardiac myosin inhibitors. Additionally, the group addresses the critical clinical and lifestyle factors involved in selecting implantable cardioverter-defibrillators (ICDs), detailing the durability advantages of subcutaneous (S-ICD) and extravascular (EV-ICD) systems for active, younger populations.</p>
May 5, 2026
Reevaluating Beta Blockers: New Evidence in Non-Obstructive HCM Care
<p>Dr. Florian Rader joins Dr. Louise Bjerregaard to discuss a groundbreaking randomized, double-blind, triple-crossover trial that challenges the long-standing "mantra" of using beta blockers as first-line therapy for non-obstructive hypertrophic cardiomyopathy (HCM). Dr. Bjerregaard explains how the study compared bisoprolol, verapamil, and placebo, revealing that bisoprolol actually resulted in a significant reduction in functional capacity and a worsening of patient symptoms as measured by the KCCQ score. The conversation explores why slowing the heart rate may be detrimental to patients with "stiff hearts" who rely on chronotropic competence to maintain cardiac output, and why calcium channel blockers like verapamil might be a more favorable alternative for symptom management. This episode is essential listening for clinicians looking to move beyond expert opinion toward evidence-based, personalized care for their non-obstructive HCM patients.</p><p>View the results of the trial here: https://www.jacc.org/doi/10.1016/j.jacc.2025.11.028</p>
April 24, 2026
The ODYSSEY Continues: Deep Diving into Non-Obstructive HCM Data
<p>Dr. James MacNamara welcomes Dr. Milind Desai from the Cleveland Clinic to dissect the results and implications of the ODYSSEY trial, the largest study ever conducted in hypertrophic cardiomyopathy (HCM). The trial investigated the use of mavacamten in patients with non-obstructive HCM, a population with significant unmet medical needs. While the study did not reach statistical significance for its primary endpoints of KCCQ score and peak VO2, Dr. Desai highlights a powerful "rowing in the same direction" effect seen in secondary data. This includes a 53% reduction in cardiac biomarkers (BNP and troponin) and favorable cardiac remodeling observed on echocardiography. The conversation explores why a strong placebo effect may have impacted the results and identifies a specific "sweet spot" responder group: patients with an ejection fraction above 65% and no history of atrial tachyarrhythmias.</p><p><strong>References:<br></strong>ODYSSEY Subgroup Analysis: <a href="https://www.jacc.org/doi/10.1016/j.jacc.2025.12.092">https://www.jacc.org/doi/10.1016/j.jacc.2025.12.092</a></p><p>ODYSSEY Exploratory Analyses: <a href="https://www.jacc.org/doi/10.1016/j.jacc.2025.12.092">https://www.jacc.org/doi/10.1016/j.jacc.2025.12.092</a></p><p>ODYSSEY-HCM Trial: <a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2505927">https://www.nejm.org/doi/full/10.1056/NEJMoa2505927</a></p>
36 total episodes available
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Frequently asked questions
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- What is In the Thick of It?
- How often does this podcast release new episodes?
This podcast updates weekly.
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This podcast is available on 9 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
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Yes, this podcast regularly features guests.
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