by Bret Scher, MD FACC
Metabolic Mind is working to transform the study & treatment of mental disorders by exploring the connection between metabolism & brain health. Metabolic interventions like ketogenic therapy are being used to treat serious mental illnesses like Bipolar Disorder, Schizophrenia, & Major Depressive Disorder. We explore topics that can help you understand how Metabolic Psychiatry might help you or a loved one treat mental disorders Watch our videos at https://www.youtube.com/@metabolicmind Our channel is for information only. Consult your physician before changing your lifestyle or medications.
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Publishing Since
3/23/2023
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April 28, 2025
<p>Creatine isn’t just for gym gains, it supports your brain too!</p><p>Creatine is best known for boosting physical performance, but research has also identified its ability to improve areas of cognitive function like memory and mood.</p><p>Research suggests that when creatine is used alongside first-line treatments, like antidepressants and CBT, it may enhance therapeutic outcomes, leading to faster and more robust improvements in symptoms.</p><p>In this interview, Dr. Nick Fabiano, a psychiatry resident and researcher at the University of Ottawa, joins Metabolic Mind to explore the emerging evidence behind creatine as a potential tool for improving mood and supporting mental health.</p><p>In this episode we dive into:</p><ul><li>What creatine is and how it works in the body and brain</li><li>The growing body of research linking creatine to improvements in depression symptoms</li><li>How creatine may enhance energy metabolism in the brain—a key focus of metabolic psychiatry</li><li>Its synergy with other treatments, including SSRIs and cognitive behavioral therapy</li><li>Practical considerations around dosing, diet, and safety</li><li>The difference between dietary and supplemental creatine</li><li>Creatine & sleep deprivation</li></ul><p>Creatine is a well-studied, widely available supplement, and its low risk profile makes it an intriguing candidate for further exploration in psychiatric care. While more research is needed, this conversation is a hopeful and informed look at a promising metabolic intervention.</p><p><br /></p><p><strong>Expert Featured:</strong></p><p>Dr. Nick Fabiano</p><p>X: <a href="https://x.com/NTFabiano?ref_src=twsrc%5Egoogle%7Ctwcamp%5Eserp%7Ctwgr%5Eauthor" rel="ugc noopener noreferrer" target="_blank">https://x.com/NTFabiano?ref_src=twsrc^google|twcamp^serp|twgr^author</a></p><p><br /></p><p><strong>Resources Mentioned:</strong></p><p>Dietary creatine intake and depression risk among U.S. adults</p><ul><li><a href="https://doi.org/10.1038/s41398-020-0741-x" rel="ugc noopener noreferrer" target="_blank">https://doi.org/10.1038/s41398-020-0741-x</a></li></ul><p>A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder</p><ul><li><a href="https://doi.org/10.1176/appi.ajp.2012.12010009" rel="ugc noopener noreferrer" target="_blank">https://doi.org/10.1176/appi.ajp.2012.12010009</a></li></ul><p>Efficacy and safety profile of oral creatine monohydrate in add-on to cognitive-behavioural therapy in depression: An 8-week pilot, double-blind, randomised, placebo-controlled feasibility and exploratory trial in an under-resourced area</p><ul><li><a href="https://doi.org/10.1016/j.euroneuro.2024.10.004" rel="ugc noopener noreferrer" target="_blank">https://doi.org/10.1016/j.euroneuro.2024.10.004</a></li></ul><p><br /></p><p><strong>CMEs Mentioned:</strong></p><p>Managing Major Mental Illness with Dietary Change: The New Science of Hope</p><ul><li><a href="https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616" rel="ugc noopener noreferrer" target="_blank">https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616</a></li></ul><p>Brain Energy: The Metabolic Theory of Mental Illness</p><ul><li><a href="https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615" rel="ugc noopener noreferrer" target="_blank">https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615</a></li></ul><p><br /></p><p>Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.</p><p>Learn more about metabolic psychiatry and find helpful resources at <a href="https://metabolicmind.org/" rel="ugc noopener noreferrer" target="_blank">https://metabolicmind.org/</a></p><p><br /></p><p><strong>About us:</strong>Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.</p><p>Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.</p>
April 25, 2025
<p>The first-ever clinical trial of ketogenic therapy for pediatric bipolar disorder is now enrolling.</p><p>In March, we announced two new initiatives funded by the Baszucki Group aiming to explore ketogenic metabolic therapy in pediatric bipolar patients.</p><p>The first major initiative—now actively enrolling participants—is a multi-site clinical trial conducted by four institutions within the Baszucki Group-funded Child and Adolescent Bipolar Network (CABIN): the UCLA Semel Institute, University of Cincinnati College of Medicine, University of Pittsburgh Medical Center, and University of Colorado Anschutz Medical Campus.</p><p>In this video, Dr. David Miklowitz, a renowned expert in adolescent bipolar disorder and the study’s lead investigator, joins Dr. Bret Scher to discuss the new trial.</p><p>As a Professor of Psychiatry at the UCLA Semel Institute and Senior Clinical Research Fellow at Oxford University, Dr. Miklowitz brings decades of insight to the discussion. Together, they explore the design and objectives of this groundbreaking study and share how families in Los Angeles, Cincinnati, Denver, and Pittsburgh can take part in this important research effort aimed at transforming outcomes for young people living with bipolar disorder.</p><p>In this interview you’ll learn:</p><p>✅ The challenges of diagnosing bipolar disorder in kids and teens</p><p>✅ How family involvement impacts long-term outcomes</p><p>✅ Why standard treatment approaches may not always work for adolescents</p><p>✅ The potential benefits of ketogenic therapy as an adjunctive treatment</p><p>For those interested in enrolling in the study, visit the link below to learn more about the study, the participant criteria, and how to enroll!</p><ul><li><a href="https://clinicaltrials.gov/study/NCT06920940?term=miklowitz&rank=1" rel="ugc noopener noreferrer" target="_blank">https://clinicaltrials.gov/study/NCT06920940?term=miklowitz&rank=1</a></li></ul><p><br /></p><p><strong>Expert Featured:</strong></p><p>Dr. David Miklowitz</p><p><a href="https://www.uclahealth.org/providers/david-miklowitz" rel="ugc noopener noreferrer" target="_blank">https://www.uclahealth.org/providers/david-miklowitz</a></p><p><strong>Resources Mentioned:</strong></p><ul><li><a href="https://www.amazon.com/Living-Well-Bipolar-Disorder-Strategies/dp/1462553532" rel="ugc noopener noreferrer" target="_blank">Living Well with Bipolar Disorder by Dr. David Miklowitz</a></li></ul><p><br /></p><p><strong>CMEs Mentioned:</strong></p><p>Managing Major Mental Illness with Dietary Change: The New Science of Hope</p><ul><li><a href="https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616" rel="ugc noopener noreferrer" target="_blank">https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616</a></li></ul><p>Brain Energy: The Metabolic Theory of Mental Illness</p><ul><li><a href="https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615" rel="ugc noopener noreferrer" target="_blank">https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615</a></li></ul><p><br /></p><p>Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.</p><p>Learn more about metabolic psychiatry and find helpful resources at <a href="https://metabolicmind.org/" rel="ugc noopener noreferrer" target="_blank">https://metabolicmind.org/</a></p><p><br /></p><p><strong>About us:</strong>Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.</p><p>Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.</p>
April 21, 2025
<p>Could ketogenic therapy change the future of autism spectrum disorder (ASD) treatment?</p><p>The CDC estimates that 1 in 36 children are affected by ASD but due to the wide variety of signs and symptoms associated, it’s likely that this doesn’t account for everyone impacted. And treatment options are scarce and vary in effectiveness.</p><p>In this video, Dr. Bret Scher sits down with Dr. Eline Dekeyster, Assistant Professor at Leiden University and Head of the Lifestyle Brain Interaction research group, to explore how nutritional ketosis may support individuals with autism and other brain-based conditions.</p><p>Dr. Dekeyster brings a rare blend of personal insight and scientific expertise. She opens up about her own experience with mood disorders and how ketosis helped shift her mental energy, leading her to dedicate her research to metabolic psychiatry.</p><p>In this episode, you’ll learn about:</p><ul><li>The early but promising evidence supporting ketogenic therapy in autism spectrum disorder</li><li>The metabolic and neurological mechanisms involved</li><li>A real-life case of a child with ASD whose symptoms improved on a ketogenic diet and the troubling response from the medical system</li><li>The challenges and strategies around adherence to ketogenic interventions in neurodivergent populations</li><li>Dr. Dekeyster’s vision for a collaborative, individualized care model that includes dietary, medical, and emotional support</li></ul><p>While more research is needed to fully understand the impact of nutritional therapies for autism spectrum disorder, ketogenic therapy may offer meaningful hope to individuals and families navigating the challenges of ASD today.</p><p><strong>Expert Featured:</strong></p><p>Dr. Eline Dekeyster</p><p><a href="https://www.instagram.com/lbi.research/" rel="ugc noopener noreferrer" target="_blank">https://www.instagram.com/lbi.research/</a></p><p><strong>CMEs Mentioned:</strong></p><p>Managing Major Mental Illness with Dietary Change: The New Science of Hope</p><ul><li><a href="https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616" rel="ugc noopener noreferrer" target="_blank">https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616</a></li></ul><p>Brain Energy: The Metabolic Theory of Mental Illness</p><ul><li><a href="https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615" rel="ugc noopener noreferrer" target="_blank">https://www.mycme.com/courses/brain-energy-the-metabolic-theory-of-mental-illness-9615</a></li></ul><p>Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.</p><p>Learn more about metabolic psychiatry and find helpful resources at <a href="https://metabolicmind.org/" rel="ugc noopener noreferrer" target="_blank">https://metabolicmind.org/</a></p><p>About us:Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.</p><p>Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.</p>
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