Race Against Mind: An Alzheimer's Prevention Investigation
Claim This Podcastby Sarah Kuhn
Podcast Overview
<p>Race Against Mind is an Alzheimer's prevention investigation hosted by Sarah Kuhn, a double APOE4 carrier with a family history of early-onset Alzheimer's disease. Instead of waiting, Sarah started asking a different question: what does the research actually say, and what happens when you take it seriously?</p><p></p><p>Each episode goes deep on one piece of the prevention puzzle: exercise, sleep, metabolic health, alcohol, hormones. Sarah breaks down the science, examines how strong it really is, and shares what she did with that information in her own life. What worked, what didn't, and what she changed her mind about along the way.</p><p></p><p>If you carry APOE4, have a family history of Alzheimer's, or simply refuse to leave your brain health to chance, this show is for you.</p>
Language
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Publishing Since
4/25/2026
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Recent Episodes
June 5, 2026
Ep. 8 The Alzheimer's Risk Factor Hidden in Your Nightly Glass of Wine
<p>I was having a glass of wine most nights when I got my Oura Ring. Not a lot, or so I thought. Within weeks the data told a different story. My HRV baseline runs in the nineties. On mornings after drinking, even one glass, it dropped to the thirties or forties. Every time. Without exception.</p><p></p><p>That data started a three-year experiment I didn't plan to run. And on December 31st, 2024, I eliminated alcohol entirely.<br /></p><p>What I expected was clarity. What I got instead, and what eventually led me to the p-tau217 test, a reinfected root canal, and a completely different understanding of why a clean baseline matters, is the story this episode tells.<br /></p><p>The research on alcohol and Alzheimer's has shifted significantly in the last few years and most people haven't caught up to it. The apparent protective effect of moderate drinking has largely collapsed under methodological scrutiny. The 2025 ALBION study found that light-to-moderate drinkers had nearly three times the odds of amyloid-beta positivity compared to abstainers. Not heavy drinkers. People who would never describe themselves as having a drinking problem. For APOE4 carriers specifically, one prospective study found that drinking at least once a month was associated with seven times the dementia risk compared to never drinking. Same behavior. Completely different biological outcome depending on what's in your DNA.</p><p></p><p>This episode covers what the research actually says, why the APOE4 picture is categorically different from the general population, what eighteen months of not drinking actually cost me socially, and the thing I least expected to learn about why elimination matters beyond optimization.</p><p></p><p><a rel="noopener noreferrer nofollow" href="https://raceagainstmind.com/episodes/alcohol-apoe4-alzheimers-risk" target="_blank">Show Notes</a></p>
May 29, 2026
Ep.7 Blueberries, Coconut Oil, and the Mediterranean Diet: What the Nutrition Research Actually Says
<p>Someone told me to give my mom coconut oil after her Alzheimer's diagnosis. My mom couldn't remember I was pregnant at the time. The person meant well. The advice was wrong. And for someone with APOE4 genetics — which both my mom and I carry — it wasn't just wrong. It was potentially the opposite of what the research supports.</p><p></p><p>That moment is where this episode starts. Because the problem isn't people giving bad advice. The problem is an information ecosystem built to capture attention rather than convey evidence. Confident nutrition claims travel faster than careful ones, and for APOE4 carriers specifically, some of what's circulating online isn't just unhelpful, it's working against you.</p><p></p><p>This is the third and final episode in the Race Against Mind nutrition series. Episodes 5 and 6 covered the personal cholesterol arc and the APOE4 lipid mechanism. This episode covers the broader nutrition research: what the science actually says about coconut oil, MCT oil, blueberries, the Mediterranean diet, omega-3s, B vitamins, ketogenic diets, and more. What's signal, what's noise, and what the internet consistently gets wrong.</p><p></p><p>The structure is deliberate: myths first, nuanced middle, then what actually has evidence. Because knowing what to be skeptical of makes the things that are genuinely supported land differently. If you've been eating well for years and wondering why nutrition advice keeps disappointing you — this episode is for you.</p><p></p><p><a rel="noopener noreferrer nofollow" href="https://raceagainstmind.com/episodes/alzheimers-nutrition-myths" target="_blank">Show Notes</a></p>
May 22, 2026
Ep. 6 APOE4, Cholesterol, and Alzheimer's Risk: What Your Lipid Panel Is Missing
<p>In February of last year, I woke up with brain fog so severe I started researching how to get a brain scan. I was convinced I had amyloid accumulating. I wanted data, not reassurance. It turned out to be a reinfected root canal. But that fear led somewhere useful — to a p-tau217 baseline test and a consulting engagement with an Alzheimer's prevention company that finally gave me the answer I'd been missing for twenty years.</p><p><br /></p><p>Sitting down to write a research paper on cholesterol and Alzheimer's risk, something clicked: of course my cholesterol is high. My APOE4 genotype makes lipid handling harder. That's not a diet failure. That's a design problem.</p><p></p><p>This episode is the science companion to Episode 5. Where Episode 5 was the lived experience of five years of dietary intervention that barely moved the needle, this episode is the explanation — why cholesterol is a fundamentally different problem for APOE4 carriers, what it actually does in the brain, and why the standard lipid panel isn't giving you the full picture.</p><p></p><p>We cover: what APOE4 actually does to lipid transport, amyloid clearance, neuroinflammation, and tau vulnerability. Why ApoB matters more than LDL for APOE4 carriers — and what the garbage bag analogy actually means for your cardiovascular and brain risk. What Lp(a) is and why you need to test it at least once. Why the connection between cardiovascular risk and Alzheimer's risk isn't two separate conversations for people with this genotype — it's one. And why understanding the mechanism finally made the statin decision obvious.</p><p></p><p>Sarah is six weeks into a statin as of this recording, with no post-statin labs yet. She also has a p-tau217 baseline in — and explains why one result doesn't tell you much, but a trend over time could tell you everything.</p><p></p><p><a rel="noopener noreferrer nofollow" href="https://raceagainstmind.com/episodes/apoe4-cholesterol-alzheimers-risk-what-lipid-panel-missing" target="_blank">Show Notes</a></p>
8 total episodes available
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- What is Race Against Mind: An Alzheimer's Prevention Investigation?
<p>Race Against Mind is an Alzheimer's prevention investigation hosted by Sarah Kuhn, a double APOE4 carrier with a family history of early-onset Alzheimer's disease. Instead of waiting, Sarah started asking a different question: what does the research actually say, and what happens when you take it seriously?</p><p></p><p>Each episode goes deep on one piece of the prevention puzzle: exercise, sleep, metabolic health, alcohol, hormones. Sarah breaks down the science, examines how strong it really is, and shares what she did with that information in her own life. What worked, what didn't, and what she changed her mind about along the way.</p><p></p><p>If you carry APOE4, have a family history of Alzheimer's, or simply refuse to leave your brain health to chance, this show is for you.</p> - How often does this podcast release new episodes?
This podcast updates daily.
- Where can I listen to this podcast?
This podcast is available on 4 platforms including Apple Podcasts, Spotify, and more. You can also use the RSS feed directly.
- Does this podcast accept guests?
No, this podcast does not typically feature guests.
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